MRI Can Help High Risk Women Detect Breast Cancer

Women who have inherited gene mutations that increase their risk for breast cancer may benefit from having annual magnetic resonance imaging (MRI) in addition to mammograms.

Defective BRCA1 and BRCA2 genes can increase a woman’s lifetime risk of getting breast cancer by 45% to 65%, according to a study published recently in the Journal of the American Medical Association. However, inherited gene mutations account for only 5% to 10% of all breast cancer cases.


Mammography is usually an effective screening tool for detecting breast cancer, but the results are not always accurate. For women with especially dense breasts, mammography can be inadequate. MRI is a much more sensitive imaging technology for these women. The drawbacks are that MRI is ten times as expensive and can increase the risk of false-positive results.

Women from families with strong histories of breast cancer often have genetic testing to learn whether they have inherited mutations in their BRCA1 and/or BRCA2 genes. If these genes are defective, they are also at higher risk for ovarian cancer.

Women with known genetic susceptibility sometimes opt to have both breasts removed (bilateral mastectomy), or they take drugs such as tamoxifen in hopes of preventing cancer. Others decide to follow screening guidelines and deal with breast cancer if and when it occurs.

After age 25, annual mammograms are recommended for women with mutations in BRCA1 and BRCA2 genes. Breast cancers are generally rare in women under age 35. For high-risk women between ages 35 and 55, annual screening with MRI and mammography would be a sound investment in their health. After age 55, women’s breasts are not as dense, and mammography alone would probably detect even small cancers.

Improvements in mammography including digital mammograms could soon make that technology almost as sensitive as MRI and also more cost effective.

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