Glucosamine and Chondroitin Not Helpful for Arthritis Treatment

A study of 1,583 patients with arthritis in the knees showed no positive effect from the two best-selling dietary supplements glucosamine and chondroitin. Three of the five patient groups involved in the study took glucosamine or chondroitin separately or a combination of both. Two other study groups took a placebo (fake) pill or Celebrex (celecoxib).

Only those taking Celebrex demonstrated statistically significant improvement in their symptoms. This recent study, published in the New England Journal of Medicine, was designed to answer perplexing questions about whether the supplements are effective.


Physicians have held out hope for their patients with arthritis that this most important and rigorous study ever conducted on the supplements would prove them to be beneficial. “It’s a null study,” said Dr. Devid Felson, a rheumatologist (arthritis specialist) at Boston University. “It doesn’t work any better than placebo.”

In 2004, Americans spent about $734 million on glucosamine and chondroitin, among the most widely used dietary supplements in the nation. More than 20 million in this country suffer from osteoarthritis, a degenerative joint disease and the most common form of arthritis.

Glucosamine and chondroitin are found naturally in joints. Many medical experts believed it might be found helpful for arthritis patients by assisting in the repair of cartilage. Their hopes were dashed in this large and comprehensive study. Previous studies were small, with no more than 100 patients, and they looked at only short-term effectiveness.

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